Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra
Identifieur interne : 000237 ( Main/Exploration ); précédent : 000236; suivant : 000238Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra
Auteurs : Hey-Kyeong Jeong [Corée du Sud] ; Ilo Jou [Corée du Sud] ; Eun-Hye Joe [Corée du Sud]Source :
- Experimental & Molecular Medicine [ 1226-3613 ] ; 2010.
Abstract
It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.
Url:
DOI: 10.3858/emm.2010.42.12.085
PubMed: 20962566
PubMed Central: 3015156
Affiliations:
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442-721</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Brain Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Brain Disease Research Center, Ajou University School of Medicine, Suwon 442-721</wicri:regionArea><wicri:noRegion>Suwon 442-721</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental & Molecular Medicine</title><idno type="ISSN">1226-3613</idno><idno type="eISSN">2092-6413</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.</p></div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Jeong, Hey Kyeong" sort="Jeong, Hey Kyeong" uniqKey="Jeong H" first="Hey-Kyeong" last="Jeong">Hey-Kyeong Jeong</name></noRegion><name sortKey="Jeong, Hey Kyeong" sort="Jeong, Hey Kyeong" uniqKey="Jeong H" first="Hey-Kyeong" last="Jeong">Hey-Kyeong Jeong</name><name sortKey="Joe, Eun Hye" sort="Joe, Eun Hye" uniqKey="Joe E" first="Eun-Hye" last="Joe">Eun-Hye Joe</name><name sortKey="Joe, Eun Hye" sort="Joe, Eun Hye" uniqKey="Joe E" first="Eun-Hye" last="Joe">Eun-Hye Joe</name><name sortKey="Joe, Eun Hye" sort="Joe, Eun Hye" uniqKey="Joe E" first="Eun-Hye" last="Joe">Eun-Hye Joe</name><name sortKey="Joe, Eun Hye" sort="Joe, Eun Hye" uniqKey="Joe E" first="Eun-Hye" last="Joe">Eun-Hye Joe</name><name sortKey="Jou, Ilo" sort="Jou, Ilo" uniqKey="Jou I" first="Ilo" last="Jou">Ilo Jou</name><name sortKey="Jou, Ilo" sort="Jou, Ilo" uniqKey="Jou I" first="Ilo" last="Jou">Ilo Jou</name><name sortKey="Jou, Ilo" sort="Jou, Ilo" uniqKey="Jou I" first="Ilo" last="Jou">Ilo Jou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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